| 1. | The priming event on the lagging strand establishes a replication fork.
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| 2. | Human PrimPol ( ccdc111 and in restarting stalled replication forks.
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| 3. | Topoisomerases are responsible for removing these supercoils ahead of the replication fork.
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| 4. | Primosomes are nucleoproteins assemblies that activate DNA replication forks.
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| 5. | DNA damage prevents the normal enzymatic synthesis of DNA by the replication fork.
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| 6. | All other proteins at the replication fork are linked directly or indirectly to DnaB.
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| 7. | The DNA helicases and polymerases must remain in close contact at the replication fork.
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| 8. | Termination requires that the progress of the DNA replication fork must stop or be blocked.
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| 9. | Gyrase is most commonly found upstream of the replication fork, where the supercoils form.
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| 10. | Spatial juxtaposition of replication sites brings "'clustering "'of replication forks.
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